One pill can change your life. -A tagline for the movie
Emily Taylor (Rooney Mara) has just been reunited w/ her loving husband- Martin (Channing Tatum- at 33 y.o.)- who served a 4 yr. jail sentence for insider trading. However, the 28 y.o. graphic designer becomes V depressed (even attempting suicide by crashing her car into a wall). At the ER, Emily convinces the consulting psychiatrist, Dr. Jonathan Banks (Jude Law), to release her instead of hospitalizing her for observation (as is commonly done). Emily explains that therapy was helpful for her in the past, and becomes his regular patient. Dr. Banks gives her some meds, BUT none of them are working for Emily. After conferring w/ her former psychiatrist, Dr. Victoria Siebert (Catherine Zeta-Jones), Dr. Banks prescribes an experimental new medication- Ablixa.
Director Steven Soderbergh considered casting Lindsay Lohan for the role of Emily and he auditioned her 3x; however, producers felt that her ongoing legal issues would disrupt the production process. Blake Lively was originally cast as Emily, BUT the production company dropped out after learning of her casting; they returned after Mara took over the role. Law (then 41 y.o.) admitted that he felt insecure playing the lead role, as it was his 1st role as a husband/ father (as in real life), the 1st time using his real accent, w/ no hair/makeup changes. Soderbergh said that one of his biggest influences making the movie was the work of Adrian Lyne, esp. Fatal Attraction (1987).
If the character should be nude in the scene and it makes sense and I trust the person making the film, then I don’t see a problem with it. I certainly don’t want to be involved in anything that is gratuitous, but I don’t think the human body is something to be ashamed of. Every other person on the planet has the same parts as I do. So seeing them shouldn’t be a huge shock to most people. -Rooney Mara
The less you know about this movie, the more you will enjoy it. I learned about it from the most recent ep of Fatal Attractions podcast. As several critics have noted, Soderbergh (who also operates the camera) doesn’t stick to just one genre in his work. Here, the viewer thinks it will one type of movie, but then it takes a different turn after about 40 mins. The screenplay (by Scott Z. Burns) is V well-written. I wasn’t a fan of the lighting that was chosen for some scenes; the yellow/green tint doesn’t look appealing. The production design was well done; most of the interiors are apts and offices of modern-day NYC. The acting was strong, aside from some of the line readings/mannerisms of Zeta-Jones; she and Tatum have appeared in other of this director’s films. The supporting cast (incl. veterans of the NYC theater) add to the story. If you enjoy thrillers and don’t mind characters who operate in the “gray area,” check this out.
 There are surprises (one of them hinted at in the opening scene) and then further and further twists.
 The screenplay is incredibly well-written, creating characters that amaze us, disappoint us and deceive us all the while being a part of an interesting and complex story. […]
It’s more of an edge-of-your-mind thriller rather than an edge-of-your- seat thriller. Never really scared, always questioning the moral and psychological behaviour of these characters.
 For half of the movie, it is a persuasive indictment of the pharmaceutical industry and its crass behavior toward its patients; for the other half, it is a three- cornered mystery/thriller, with double crosses and framings galore.
-Excerpts from IMDb reviews